Investigating COVID-19 Host Genetics
Uncovering the underlying factors that contribute to host susceptibility and immune response is essential to unravel the complexities of COVID-19. It is crucial to understand how genetic variance contributes to susceptibility as well as define how the immune system responds during the course of the disease. Illumina genomics solutions allow researchers to interrogate host genetic variance and profile the molecular mechanisms that drive immune responses.
The key benefits of using Illumina technology for studying the immune response to COVID-19 include:
- Scalability to screen diverse sample sets
- Solutions to enable a multi-omic approach to understand host genetics and immune response
- Analysis solutions to match your project scale
Methods for Host Risk & Immune Response Studies
| Application | Goal | Recommended Methods |
|---|---|---|
| Host genetics research |
|
|
| Host immune response profiling |
|
|
| Microbiome & host response |
|
Illumina to Sequence Genomes for New UK-wide COVID-19 Study
Data from severely ill patients may help us understand the genetics of susceptibility.Featured Workflows
Webinar: COVID-19 Host Genetics Initiative
Mark Daly, PhD discusses a global effort to identify host genetics contributions to COVID-19 disease susceptibility and severity.
Access WebinarUsing Genomics to Study COVID-19 Host Genetic Variability
Dr. Lee Murphy’s core lab at the University of Edinburgh applies a genomic approach to study host genetic variability in disease progression and outcome in SARS-CoV-2 hospitalized patients. The team and collaborators perform genotyping and WGS on DNA samples, as well as mRNA-Seq on the NextSeq 2000 System.
View Video
Collaborative Environment for COVID-19 Host Response Research
BaseSpace Correlation Engine enables and accelerates COVID-19 research.Featured Host Genetics & Immune Response Publications
High-throughput SARS-CoV-2 and host genome sequencing from single nasopharyngeal swabs
Read PaperPresence of Genetic Variants Among Young Men with Severe COVID-19
Read PaperCOVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis
Read PaperGet help finding the right solutions for your host genetics and immune response studies.
Related Solutions
Microbiome Analysis
The study of microbial communities found in and on the human body allows researchers to understand the role of microbes in health and disease.
Shotgun Metagenomics
A DNA sequencing method that enables comprehensive sampling of all genes in all organisms in a given complex microbial sample.
Complex Disease Research
Complex diseases result from a combination of genetic and environmental factors. Array and sequencing technologies can help reveal the underpinnings of these diseases.
Cell & Molecular Biology
Expand cell and molecular biology research beyond conventional methods with next-generation sequencing.
Single-Cell RNA-Seq
With single-cell RNA-Seq, researchers can study cellular differences that are often masked by bulk sampling.