Ordering the NextSeq 550Dx Instrument

Order a NextSeq 550Dx Instrument today. Speak to a representative for information on pricing, availability, and more.

An IVD-regulated mid-throughput sequencing platform for clinical laboratories. Dual research and diagnostic modes support the flexibility to perform IVD testing, LDT development, and clinical research on a single instrument. 

This product is only available in select locations. Please select the location where you would like this product to be shipped to see availability.

Product claims in some countries may vary based on applicable local regulatory requirements and the scope of regulatory approvals. Please refer to the product labeling applicable to your country for product claims. This product may not be available in all countries. Contact an Illumina representative for regional availability. 

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How do I prepare for my Illumina instrument delivery?

In this video, an Illumina Field Applications Scientist discusses what to expect during the preinstallation, shipping, and delivery stages. We’ll highlight important steps in the process and introduce you to available resources.

Library preparation is a required sequencing step. Use our selection tool to determine the best library prep kit for your needs based on your application, method, species and more.

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Instrument (1)

NextSeq™ 550Dx Sequencing System

20005715

The NextSeq 550Dx instrument is intended for sequencing of DNA libraries when used with in vitro diagnostic assays performed on the instrument. The NextSeq 550Dx instrument is to be used with specific registered, certified or approved in vitro diagnostic reagents and analytical software.The instrument includes a dual boot configuration to enable the use of the instrument in either diagnostic (Dx) or research use only (RUO) mode. In vitro diagnostic sequencing assays, including the Germline and Somatic Variant Modules, are executed in diagnostic mode. Only IVD sequencing reagents can be utilized in diagnostic mode.

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Reagents (2)

NextSeq 550Dx High Output Reagent Kit v2.5 (75 cycles) IVD

20028870

Includes one high output flow cell, one buffer cartridge, and one reagent cartridge containing clustering and sequencing reagents to support a 75-cycle run on the NextSeq 550Dx System. All products registered for In Vitro Diagnostic sequencing.

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NextSeq 550Dx High Output Reagent Kit v2.5 (300 cycles) IVD

20028871

Includes one high output flow cell, one buffer cartridge, and one reagent cartridge containing clustering and sequencing reagents to support a 300-cycle run on the NextSeq 550Dx System. All products registered for In Vitro Diagnostic sequencing.

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Selection summary

Product

Qty

Unit Price

Required products

NextSeq 550Dx High Output Reagent Kit v2.5 (75 or 300 cycles) 

Library prep kit for IVD assay development or RUO use

IVD assay development: Illumina DNA Prep with Enrichment Dx

RUO applications: library prep kit for your chosen application and method


Optional products:

Air filter replacement (recommended every 90 days) 

/ Results

FAQs

In Dx Mode, the NextSeq 550Dx Instrument supports targeted sequencing using Illumina DNA Prep with Enrichment Dx. Additionally, Veriseq NIPT Solution v2, TruSight Oncology Comprehensive (EU), and other commercially available third-party IVD assays are also available on the NextSeq 550Dx Instrument.

The NextSeq 550Dx Instrument offers a Diagnostic Mode (Dx Mode) and a Research Mode (RUO Mode). These dual modes provide the flexibility to perform IVD testing, LDT development, and clinical testing on a single instrument. Runs performed in Dx Mode are processes regulated by US and EU regulatory bodies. Learn more about developing IVD assays or contact an Illumina representative for more information about IVD development partnerships.

To design custom assays on the NextSeq 550Dx Instrument, use the Illumina DNA Prep with Enrichment Dx kit, a library prep and enrichment solution for IVD targeted sequencing applications. This kit enables clinical labs to add targeted sequencing to their menu of diagnostic applications and offers a core component of the IVD assay pathway for performing validated NGS tests. 

The NextSeq 550Dx Instrument in RUO Mode supports all currently available clinical applications, including exome sequencing, transcriptome profiling, user-designed targeted panels, and microarray scanning. To learn more, visit the NextSeq 550 System applications and methods page.

See the similarities and differences between all Illumina IVD instruments here. Contact an Illumina representative with questions about choosing the right instrument for you.

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Illumina DNA Prep

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Intended use for the NextSeq 550Dx Instrument

United States:

The NextSeq 550Dx Instrument is intended for targeted sequencing of DNA libraries from human genomic DNA extracted from peripheral whole blood or formalin-fixed, paraffin-embedded (FFPE) tissue when used with in vitro (IVD) diagnostic assays. The NextSeq 550Dx Instrument is not intended for whole genome or de novo sequencing. The NextSeq 550Dx Instrument is to be used with specific registered, certified, or approved in vitro diagnostic reagents and analytical software.

European Union:

The NextSeq 550Dx instrument is intended for sequencing of DNA libraries when used with in vitro diagnostic assays. The NextSeq 550Dx instrument is to be used with specific registered, certified, or approved in vitro diagnostic reagents and analytical software.

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