Personal and Clinical Utility of Polygenic Risk Scores:

This webinar provides an overview of polygenic risk scores, which aggregate dozens of genetic variants that have been linked to disease risk in genome-wide association studies (GWAS) into a single score.

Recently there has been growing interest in polygenic risk scores for predicting disease risk, expanding on the value of large GWAS. Various efforts have begun to demonstrate the utility of polygenic risk profiling to identify groups of individuals who could benefit from the knowledge of their probabilistic susceptibility to disease.

This talk will review the evidence supporting the personal and clinical utility of polygenic risk profiling and how it can be transformative for clinical care as well as drug discovery.

More specifically this webinar:

• Describes the polygenic basis for common diseases.

• Describes how polygenic risk scores are generated. What are the various strategies?

• The utility of polygenic risk scores from multiple perspectives.

• Discusses “Genotype First” as a framework for the ethical use of genetics.

Speaker:

Ali Torkamani
Director of Genomics and Genome Informatics,
Scripps Research Translational Institute