Comprehensive Genomic Profiling (CGP) is becoming a critical component for evaluating treatment options in oncology patients. The ideal CGP assay provides information on both standard-of-care and emerging molecular biomarkers, maximizes information obtained from limited biopsy samples, and is straightforward to implement and operate in the pathology laboratory. Dr. Swat will present his experience in implementing CGP in-house using a hybrid capture-based CGP assay and discuss its impact in clinical practice at GenPath Oncology.