DRAGEN Array

DRAGEN Array provides accurate, comprehensive and efficient secondary analysis for Infinium microarrays.

Overview

DRAGEN (Dynamic Read Analysis for GENomics) Array secondary analysis is a powerful bioinformatics software for Infinium array-based assays. DRAGEN Array uses cutting-edge data analysis tools to provide accurate, comprehensive, and highly efficient secondary analysis to maximize genomic insights and meet your research needs.

Accurate and efficient analysis

High quality, rapid results for multiple applications including genotyping, pharmacogenomics (PGx) analysis, and methylation QC.

Comprehensive workflow

DRAGEN Array is part of the comprehensive Infinium microarray solution. Choose from custom, semi-custom or ready-to-use microarrays with expertly designed content; then process, scan and analyze data with a rapid DNA-to-data workflow. 

Cloud and local deployment

DRAGEN Array offers a local, command-line package (no specialized field programmable gate array (FPGA) server or hardware required) and a cloud-based package with an intuitive graphical user interface (GUI).


Specifications


Software updates

DRAGEN Array features include:

  • Single nucleotide variant (SNV) genotyping analysis from any human Infinium microarray

  • Pharmacogenomics (PGx) analysis pipeline

  • PGx copy number variant (CNV) calling, star allele calling, and metabolizer status for Infinium Global Diversity Array with Enhanced PGx BeadChips

  • Methylation QC analysis

  • See the release notes for additional information and the full list of features.

Applications

DRAGEN Array provides accurate, comprehensive and efficient secondary analysis for Infinium microarrays.

  Description Variant types detected Local analysis Cloud analysis
Genotyping Provides greater than 99.5% genotyping accuracy for any human Infinium genotyping array1. SNV​
Indel
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PGx – CNV calling​ Provides greater than 95% PGx CNV accuracy2. PGx CNV coverage on 6 target genes across 9 target regions.​ SNV​
Indel​
CNV
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PGx – star allele annotation​​ Provides PGx star allele and variant coverage across 1700+ targets for 50+ genes. Assess hard to discern PGx genes, including the elusive CYP2D6 with greater than 98% call rate3.​​ SNV​
Indel​
CNV
Star allele diplotype​
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Methylation QC​ Provides high-throughput, quantitative methylation quality control.​ Methylation metrics ​  
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For more information visit: https://help.dragenarray.illumina.com/overview/our-features

Example workflow

1
Select content
3
Track, analyze and report

DRAGEN Array


Related applications and methods

Documentation

Product literature

Figures

DRAGEN Array cloud analysis, step 1

Navigate to 'Runs – Microarray Analysis Setup' to get started with analysis.

DRAGEN Array cloud Analysis, step 2

Set up the analysis configuration.

DRAGEN Array cloud analysis, step 3

Select sample for analysis with Import Sample Sheet, Select BeadChips, or Import IDAT Files.

DRAGEN Array cloud analysis, step 4

View your results.

Efficient PGx analysis

Genotyping, PGx CNV calling, and star allele annotation in a single platform producing multiple output options.

Star allele annotation

Example of a star allele annotation JSON file to be used in downstream processing. Provides supporting variants, missing variants and alleles tested.

Methylation QC with adjustable thresholds

21 control metrics assess the quality of outputs. Adjustable pass/fail thresholds accommodate scanner differences,​ sample type differences, or study design preferences​​.

Software options (2)

DRAGEN Array Local - star allele annotation

20109885

Per sample analysis quota for star allele calling using DRAGEN Array Local. One per sample analysis quota is needed per sample analyzed for star allele calling using the star-allele call subcommand. DRAGEN Array Local is a command-line software with no FPGA hardware or specialized server required and is downloadable from the Illumina Support Site. Internet is required for per sample quota check.

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DRAGEN Array Cloud - star allele annotation

20109886

Per sample analysis quota for star allele calling using DRAGEN Array Cloud. One per sample analysis quota is needed per sample analyzed for star allele calling using the analysis type, DRAGEN Array – PGx – star allele calling. DRAGEN Array Cloud provides analysis kickoff using BaseSpace Sequence Hub. The BaseSpace Sequence Hub access is facilitated by an Illumina Connected Analytics (Basic, Professional, or Enterprise) annual subscription. iCredits are used to store data on the cloud platform.

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Data analysis and storage (8)

Illumina Analytics - 1 iCredit

20042038

iCredits are used for data storage and analysis on either BaseSpace Sequence Hub or Illumina Connected Analytics.

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Illumina Analytics  Starter Pack - 1,000 iCredits

20042039

iCredits are used for data storage and analysis on either BaseSpace Sequence Hub or Illumina Connected Analytics.

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Illumina Analytics  - 5,000 iCredits

20042040

iCredits are used for data storage and analysis on either BaseSpace Sequence Hub or Illumina Connected Analytics.

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Illumina Analytics  - 50,000 iCredits

20042041

iCredits are used for data storage and analysis on either BaseSpace Sequence Hub or Illumina Connected Analytics.

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Illumina Analytics - 100,000 iCredits

20042042

iCredits are used for data storage and analysis on either BaseSpace Sequence Hub or Illumina Connected Analytics.

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ICA Basic Annual Subscription

20044874

Illumina Connected Analytics (ICA) Basic Annual Subscription. This product includes 1 year of access to ICA Basic, including sequencing instrument connectivity, data management capabilities, and access to pre-packaged analysis tools.

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ICA Professional Annual Subscription

20044876

Illumina Connected Analytics (ICA) Professional Annual Subscription. This product includes 1 year of access to ICA, including sequencing instrument connectivity, data management capabilities, access to pre- packaged tools, and the ability to create customized workflows composed of tools, pipelines, data warehouses, and notebooks.

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ICA Enterprise Annual Subscription

20038994

Illumina Connected Analytics (ICA) Enterprise Annual Subscription. This product includes 1 year of access to ICA Enterprise, including sequencing instrument connectivity, data management capabilities, custom and pre-packaged analysis tools, and the Base module for data warehousing and mining. ICA Enterprise also includes optional HIPAA BAA (US-only), single sign-on (SSO), and a service level agreement (SLA).

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References

1,2,3 - Illumina data on file, 2023. Read more

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