DRAGEN Array

DRAGEN Array provides accurate, comprehensive and efficient secondary analysis for Infinium microarrays.

High-throughput Infinium™ methylation array QC using DRAGEN™ Array Methylation QC software
Technical note PDF < 1 MB

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Overview
Applications
Documentation
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Overview

DRAGEN (Dynamic Read Analysis for GENomics) Array secondary analysis is a powerful bioinformatics software for Infinium array-based assays. DRAGEN Array uses cutting-edge data analysis tools to provide accurate, comprehensive, and highly efficient secondary analysis to maximize genomic insights and meet your research needs.

Accurate and efficient analysis

High quality, rapid results for multiple applications including genotyping, pharmacogenomics (PGx) analysis, and methylation QC.

Comprehensive workflow

DRAGEN Array is part of the comprehensive Infinium microarray solution. Choose from custom, semi-custom or ready-to-use microarrays with expertly designed content; then process, scan and analyze data with a rapid DNA-to-data workflow.

Cloud and local deployment

DRAGEN Array offers a local, command-line package (no specialized field programmable gate array (FPGA) server or hardware required) and a cloud-based package with an intuitive graphical user interface (GUI).

Specifications

Instruments	iScan System
Method	Methylation array, High-throughput genotyping array, Genome-wide genotyping array, Targeted genotyping array
Nucleic acid type	DNA
Software format	Cloud, On-premises
Species category	Human
Technology	Microarray
Variant class	Single nucleotide polymorphisms (SNPs), Insertions-deletions (indels), Copy number variants (CNVs)

Software updates

DRAGEN Array features include:

Single nucleotide variant (SNV) genotyping analysis from any human Infinium microarray
Pharmacogenomics (PGx) analysis pipeline
PGx copy number variant (CNV) calling, star allele calling, and metabolizer status for Infinium Global Diversity Array with Enhanced PGx BeadChips
Methylation QC analysis
See the release notes for additional information and the full list of features.

Applications

DRAGEN Array provides accurate, comprehensive and efficient secondary analysis for Infinium microarrays.

	Description	Variant types detected	Local analysis	Cloud analysis
Genotyping	Provides greater than 99.5% genotyping accuracy for any human Infinium genotyping array¹.	SNV Indel	checkmark Icon not available	checkmark Icon not available
PGx – CNV calling	Provides greater than 95% PGx CNV accuracy². PGx CNV coverage on 6 target genes across 9 target regions.	SNV Indel CNV	checkmark Icon not available	checkmark Icon not available
PGx – star allele annotation	Provides PGx star allele and variant coverage across 1700+ targets for 50+ genes. Assess hard to discern PGx genes, including the elusive CYP2D6 with greater than 98% call rate³.	SNV Indel CNV Star allele diplotype	checkmark Icon not available	checkmark Icon not available
Methylation QC	Provides high-throughput, quantitative methylation quality control.	Methylation metrics		checkmark Icon not available

For more information visit: https://help.dragenarray.illumina.com/overview/our-features

Example workflow

Select content

Infinium microarrays

Process and scan

Track, analyze and report

DRAGEN Array

Related applications and methods

Pharmacogenomics

Pharmacogenomics, the study of how variations in the human genome affect our response to medications, may help reduce adverse drug reactions and medical costs.

Polygenic Risk Scores

Polygenic risk scores represent the total number of genetic variants an individual has that increase their risk of developing a particular disease.

Methylation Arrays | Analyze methylation sites across the genome

Methylation arrays enable high-throughput, quantitative interrogation of methylation sites across the genome at single-nucleotide resolution.

Documentation

Product literature

DRAGEN Array secondary analysis
Brochure PDF < 1 MB

High-throughput Infinium™ methylation array QC using DRAGEN™ Array Methylation QC software
Technical note PDF < 1 MB

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Data sheet PDF < 1 MB

5 versions

Support documentation

DRAGEN Array User Guide Documentation

DRAGEN Array Support Documentation

DRAGEN Array Developer Documentation

Figures

DRAGEN Array cloud analysis, step 1

Navigate to 'Runs – Microarray Analysis Setup' to get started with analysis.

DRAGEN Array cloud Analysis, step 2

Set up the analysis configuration.

DRAGEN Array cloud analysis, step 3

Select sample for analysis with Import Sample Sheet, Select BeadChips, or Import IDAT Files.

DRAGEN Array cloud analysis, step 4

View your results.

Efficient PGx analysis

Genotyping, PGx CNV calling, and star allele annotation in a single platform producing multiple output options.

Star allele annotation

Example of a star allele annotation JSON file to be used in downstream processing. Provides supporting variants, missing variants and alleles tested.

Methylation QC with adjustable thresholds

21 control metrics assess the quality of outputs. Adjustable pass/fail thresholds accommodate scanner differences, sample type differences, or study design preferences.

Software options (2)

DRAGEN Array Local - star allele annotation

20109885

Per sample analysis quota for star allele calling using DRAGEN Array Local. One per sample analysis quota is needed per sample analyzed for star allele calling using the star-allele call subcommand. DRAGEN Array Local is a command-line software with no FPGA hardware or specialized server required and is downloadable from the Illumina Support Site. Internet is required for per sample quota check.

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DRAGEN Array Cloud - star allele annotation

20109886

Per sample analysis quota for star allele calling using DRAGEN Array Cloud. One per sample analysis quota is needed per sample analyzed for star allele calling using the analysis type, DRAGEN Array – PGx – star allele calling. DRAGEN Array Cloud provides analysis kickoff using BaseSpace Sequence Hub. The BaseSpace Sequence Hub access is facilitated by an Illumina Connected Analytics (Basic, Professional, or Enterprise) annual subscription. iCredits are used to store data on the cloud platform.

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