This video shows how to use Streptavidin Magnetic Beads (SMB) to capture probes hybridized to the targeted regions of interest. Subscribe to the Illumina video channel http://www.youtube.com/subscription_center?add_user=IlluminaInc A global genomics leader, Illumina provides comprehensive next-generation sequencing solutions to the research, clinical, and applied markets. Through collaborative innovation, Illumina is fueling groundbreaking advancements in oncology, reproductive health, genetic disease, microbiology, agriculture, forensic science, and beyond. View customer spotlight videos https://www.youtube.com/playlist?list=PLKRu7cmBQlajfheLzgbI4S7xBn7IDbt79 View Illumina webinars https://www.youtube.com/playlist?list=PLKRu7cmBQlahpXlnrrXlQw9itVJ8yHwUZ View Illumina support videos https://www.youtube.com/playlist?list=PLKRu7cmBQlajbm2KGsICWb-JOnusJfYvM LinkedIn: https://www.linkedin.com/company/illumina X: https://x.com/illumina Instagram: https://www.instagram.com/illuminainc/ Facebook: https://www.facebook.com/illuminainc TikTok: https://www.tiktok.com/@illuminainc #IlluminaLibraryPrep #BeadHandlingBestPractices #illumina 00:00 Introduction 00:08 Vortex SMB beads and add to a MIDI plate, add samples 02:02 Incubation steps including magnetic plate 02:20 Remove supernatant from wells 02:51 Wash beads on magnetic stand with EEW 05:47 Add elution mix to wells over pellet 06:32 Incubation steps 06:50 Transfer eluate to new PCR plate