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    Infinium OncoArray-500K BeadChip

    This comprehensive, high-density microarray kit enables research into cancer predisposition and risk.

    ~2,304 sa…

    Sample throughput

    Fixed mar…

    Number of markers

    See full details in the specifications table

    Overview

    The Infinium OncoArray-500K contains 500,000 SNPs with a genome-wide backbone of 250,000 tag SNPs. Additional SNPs include genetic variants associated with breast, colorectal, lung, ovarian, and prostate cancers plus SNPs covering ancestry, quantitative traits, pharmacogenetics, and fine-mapping of common cancer susceptibility loci. To support additional research requirements, the Infinium OncoArray-500K can be tailored to incorporate up to 120,000 custom beadtypes.*

    The Infinium OncoArray-500K was developed in collaboration with leading experts from the OncoArray consortium†, and draws on many of the features of the successful Collaborative Oncological Gene-environment Study (iCOGS) array1. Designed with candidate SNPs identified by the consortium, the OncoArray provides a cost-effective means to assess candidate variants potentially associated with cancer risk.

    The Infinium OncoArray-500K uses a 24-sample high-throughput screening (HTS) BeadChip to enable maximum throughput, productivity, and genotyping accuracy. Using the proven iScan System, the Infinium OncoArray-500K is designed to combine affordability with high-density content, providing insight into the relationship between gene variants and cancer predisposition in five of the most prevalent cancers.

    * For additional information about custom add-on content, contact your Illumina account manager or sales specialist.

    View Manifest (Array Content) Files

    Specifications

    Assay type Infinium HTS
    Automation capability Automated array loader, Liquid handling robot(s)
    Input quantity 200 ng
    Instruments iScan System
    Method Targeted genotyping array
    Nucleic acid type DNA
    Number of markers Fixed markers: ~500,000
    Custom marker add-on capacity: Up to 120,000 (with + kit versions)
    Sample throughput ~2,304 samples per week
    Species category Human
    Technology Microarray
    Variant class Single nucleotide polymorphisms (SNPs), Germline variants, Structural variants, Insertions-deletions (indels), Copy number variants (CNVs)

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    References

    1. www.nature.com/icogs/primer/cogs-project-and-design-of-the-icogs-array

    † The OncoArray consortium is an international collaboration of leading experts from the NCI-supported Genetic Association and Mechanisms in Oncology (GAME-ON) consortium, Genome Canada, Genome Quebec, and Cancer Research UK.

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