At AGBT 2026, Carrie Cibulskis (Broad Clinical Labs) presents advances in multiomic profiling of pediatric cancers using plasma circulating tumor DNA (ctDNA). This talk highlights the BrightSeq initiative, combining whole genome sequencing, targeted panels, and Illumina 5-base chemistry to integrate genomic and methylation signals from limited pediatric samples. The approach enables detection of copy number changes, structural variants, and somatic mutations while adding epigenomic insights through differentially methylated regions (DMRs). Early results show strong concordance with standard methods and improved sensitivity in identifying tumors—especially challenging subtypes like malignant rhabdoid kidney tumors. By enabling non-invasive tumor detection and better disease stratification, this workflow has the potential to improve clinical trial design, monitor treatment response, and guide therapy decisions in pediatric oncology. Subscribe to the Illumina video channel http://www.youtube.com/subscription_center?add_user=IlluminaInc A global genomics leader, Illumina provides comprehensive next-generation sequencing solutions to the research, clinical, and applied markets. Through collaborative innovation, Illumina is fueling groundbreaking advancements in oncology, reproductive health, genetic disease, microbiology, agriculture, forensic science, and beyond. View customer spotlight videos https://www.youtube.com/playlist?list=PLKRu7cmBQlajfheLzgbI4S7xBn7IDbt79 View Illumina webinars https://www.youtube.com/playlist?list=PLKRu7cmBQlahpXlnrrXlQw9itVJ8yHwUZ View Illumina support videos https://www.youtube.com/playlist?list=PLKRu7cmBQlajbm2KGsICWb-JOnusJfYvM LinkedIn: https://www.linkedin.com/company/illumina X: https://x.com/illumina Instagram: https://www.instagram.com/illuminainc/ Facebook: https://www.facebook.com/illuminainc TikTok: https://www.tiktok.com/@illuminainc #illumina #AGBT2026 #PediatricCancer #ctDNA #Genomics #Epigenomics #Multiomics #LiquidBiopsy #TranslationalResearch #Illumina