Pillar® oncoReveal™ Multi-Cancer CNV + RNA Fusion Panel

A pan-cancer panel with combined DNA/RNA content, utilizing the single-tube SLIMamp™ workflow for fast library prep and turnaround time.

~6.5 hr

Assay time

~3 hr

Hands-on time

5-80ng DNA, 10-50ng RNA

Input quantity

See full details in the specifications table

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Overview
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Overview

The oncoReveal™ Multi-Cancer with CNV and RNA Fusion Panel is a combined DNA/RNA multi-cancer panel. The assay combines the DNA-based ONCO/Reveal Multi-Cancer v4 with CNV Panel with the ONCO/Reveal Multi-Cancer RNA Fusion v2 Panel allowing for joint sequencing. The assay uses proprietary Stem Loop Inhibition-Mediated amplification (SLIMamp®) technology, a tiled amplicon-based library prep chemistry for efficient single-tube target enrichment.

Maintain control of samples and results with single-tube, tiled amplification that can be performed in-house by any NGS lab
Achieve variant detection as low as 1% VAF without UIDs, even with limited DNA input or poor sample quality
Improve lab efficiency and reduce “no calls”, repeat testing and difficult interpretation decisions
< 8 hours DNA to sequencer, < 9-10 hours RNA to sequencer

Specifications

Assay time	~6.5 hr
Cancer type	Pan-cancer, Solid tumor
Content specifications	78- gene small pan-tumor oncology panel
Description	78- gene amplicon-based panel with DNA & RNA content, simple single tube workflow
Hands-on time	~3 hr
Input quantity	5-80ng DNA, 10-50ng RNA
Instruments	MiSeq System, NextSeq 550 System, MiSeqDx in Research Mode, NextSeq 550Dx in Research Mode, MiSeq i100 System, MiSeq i100 Plus System
Mechanism of action	Multiplex PCR using tiled amplicon
Method	Targeted DNA sequencing, Amplicon sequencing, Targeted RNA sequencing
Nucleic acid type	DNA, RNA
Number of amplicons	Pool 1 (DNA): 341 amplicons. Pool 2 (RNA): <80 amplicons plus MET exon 14 skipping
Number of reactions	24 DNA/24 RNA
On-target reads	99.5% ± 0.1%
Specialized sample types	Blood, Low-input samples, FFPE tissue
Species category	Human
Target insert size	Average: 120bp (range 86-185bp)
Technology	Sequencing
Uniformity	98.2% ± 0.7%
Variant class	Gene fusions, Somatic variants, Single nucleotide variants (SNVs), Insertions-deletions (indels), Copy number variants (CNVs)

Required products

Pillar® oncoReveal™ panels require the use of a Pillar index kit.

What accessories do I need?

Pillar® oncoReveal™ panels require the use of a Pillar index kit. Pick your preferred number of reactions.

/ Results

Applications

Example workflow

Prep

Pillar® oncoReveal™ Multi-Cancer CNV + RNA Fusion Panel

Sequence

Analyze

Documentation

Product literature

Literature is not currently available for this product.

Support documentation

All Pillar oncoReveal Panels Support

Figures

Gene list

Panel specifications

oncoReveal™ Multi-Cancer CNV + Fusion

HNA-HS-1001-48

oncoReveal™ Multi-Cancer CNV + Fusion

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Indices PI501-8, PI701-4 (32 combinations, 96 reactions)

IDX-PI-1001-96

Indices PI501-8, PI701-4 (32 combinations, 96 reactions)

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Kit D, indices PI501-8, PI701-12

IDX-PI-1004-192

Kit D, indices PI501-8, PI701-12

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Pillar® oncoReveal™ Multi-Cancer CNV + RNA Fusion Panel

~6.5 hr

~3 hr

5-80ng DNA, 10-50ng RNA

Overview

Specifications

Required products

Applications

Example workflow

Prep

Sequence

Analyze

Documentation

Product literature

Support documentation

Figures

Gene list

Panel specifications

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Pillar® oncoReveal™ Multi-Cancer CNV + RNA Fusion Panel

~6.5 hr

~3 hr

5-80ng DNA, 10-50ng RNA

Overview

Specifications

Required products

What products do I need?

Applications

Example workflow

Prep

Sequence

Analyze

Documentation

Product literature

Support documentation

Figures