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人类联盟

Illumina通过人类联盟帮助世界各地的生物医学研究人员共同设计并运行定制基因组学分析。联盟由Illumina进行协调,成员之间互相共享资源,最终使所有人获益。

联盟产品包括功能强大的基因分型芯片以及其他新一代基因组学分析工具。人类联盟可以是公开的,也可以是保密的。从定制内容、项目管理到生物信息学,Illumina为人类联盟成员提供了综合性解决方案。以下是我们目前公开的人类联盟产品。

Consortia Boosters to Flagship Arrays

Contains about 50,000 SNPs fine-mapping content derived from exome sequencing and meta-analysis of phenotype-specific consortia to drive clinical research of the following traits:

  • Psychiatric
  • Neurological
  • Cancerous
  • Cardiometabolic
  • Autoimmune
  • Anthropometric

Available as add-on content to:

The Multi-Disease Booster may combine with other boosters or base content. Contact your Sales Rep for more information.

Features about 30,000 markers from the Infinium PsychArray-24 BeadChip associated with common psychiatric disorders to inspire psychiatric research including:

  • Schizophrenia
  • Bipolar disorder
  • Autism spectrum disorders
  • Attention deficit hyperactivity disorder
  • Major depressive disorders
  • Obsessive compulsive disorder
  • Anorexia
  • Tourette's syndrome

Available as add-on content to:

The Psych Booster may combine with other boosters or base content. Contact your Sales Rep for more information.

Contains 28,000 SNPs curated content focused on a wellness and lifestyle, direct-to-consumer (DTC) application contributed by a consortium of DTC customers

Available as add-on content to:

The Direct-To-Consumer Booster may combine with other boosters or base content. Contact your Sales Rep for more information.

Features about 75,000 SNPs neurodegenerative diseases-concentrated booster to enable rigorous genetic investigation of monogenic cases of Parkinson’s Disease. The Neuro Booster is an update of the NeuroChip Consortium contributed by a consortium led by National Institute of Aging for the Global Parkinson’s Genetics Program. It will enable discovery, fine mapping, polygenic risk score analysis, and replication of previously identified genetic variants associated with common neurodegenerative diseases including:

  • Alzheimer’s Disease
  • Parkinson’s Disease
  • Amyotrophic Lateral Sclerosis (ALS)
  • Multiple Sclerosis (MS)
  • Progressive Supranuclear Palsy (PSP)/Corticobasal degeneration (CBD)
  • Multiple System Atrophy (MSA)
  • Frontotemporal Dementia (FTD)
  • Dementia with Lewy Bodies (DLB)

Learn more about Global Parkinson’s Genetics Program: https://parkinsonsroadmap.org/gp2/

Available as add-on content to:

Contact your Sales Rep for more information.

Features over 90,000 SNPs for studying breast cancer in women and men of multiple ancestries. The Confluence Booster will enable discovery of variants for breast cancer risk overall and by subtype, develop multi-ancestry polygenic risk scores for personalized risk assessment and uncover variants for breast cancer survival, pharmacogenomics, and second cancers. The content is carefully selected by National Cancer Institute by leveraging experience with polygenic risk scores for predicting breast cancer across different ancestry groups and subtypes. The Confluence Booster includes:

  • Novel variants and highly penetrant mutations identified in CARRIERS, BRIDGES, PERSPECTIVE I&I, BRA-STRAP, AABCGS and ENIGMA
  • Known pathogenic variants in breast cancer genes such as BRCA1, BRCA2, ATM, PALB2 and CHEK2.

Learn more about the Confluence project: https://dceg.cancer.gov/research/cancer-types/breast-cancer/confluence-project

Available as add-on content to:

Contact your Sales Rep for more information.

Features pan-ethnic coverage sequence, structural variants of >300 autosomal, X-linked recessive diseases with high detection rates and low residual risk, including:

  • Spinal Muscular Atrophy
  • Duchenne Muscular Dystrophy
  • Cystic Fibrosis
  • Hemoglobinopathies
  • Fragile X (requires separate assay)

End-to-end solution available through partnership with Igentify for interpretation.

Available as add-on content to:

The third-party analysis may not be available in some regions. Contact your Sales Rep for more information.

开放的人类联盟

H3Africa Consortium Array

H3Africa Consortium旨在为研究人员提供顶尖的基因组学工具,用于研究影响疾病易感性和药物反应的环境和遗传因素。基于MEGA芯片骨架构建并含有非洲各地人群个体新型全基因组内容的H3Africa Consortium Array1是全面、高效的非洲基因组研究芯片。H3Africa数据将为解决健康不平衡问题提供战略信息,有利于推动非洲及其他地区人群的健康。

深入了解该联盟

Infinium H3Africa Consortium Array

A powerful array for genetic studies focused on African populations.

Read Data Sheet

加入人类联盟

希望加入现有的人类疾病研究联盟或启动一个新联盟?联系我们.

基因分型研究

探索基于测序和芯片的基因分型解决方案,以获取遗传变异对功能的影响相关信息。

了解更多

人类联盟产品

Infinium DrugDev Consortium Array

这款基因分型芯片由转化基因组学和计算生物学领域的领军人物合作开发,使得研究人员能够在开发早期更高效地筛选潜在的药物靶点。深入了解该联盟

Infinium Neuro Consortium Array

Neuro Consortium Array由神经基因组学领域的合作伙伴设计,用以研究神经退行性疾病中基因组学的作用。该联盟将已知的神经退行性疾病基因中发现的所有已鉴定标记物整合到同一芯片中。

The Neuro Consortium Array is now available with updated content as the Neuro Booster.深入了解该联盟

TruSeq Neurodegeneration Panel

该测序panel包括有关主要神经退行性疾病的专家精选内容,可使研究人员能够经济高效地完成靶向基因的编码和非编码区域研究。该panel将Nextera文库制备和富集技术与久经验证的Illumina测序及数据分析技术相结合,打造了综合的工作流程。深入了解该panel

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更多资源

Shared Vision for the Power of Human WGS
人类WGS的力量

基因组学领域的领军人物们就临床研究中高通量和群体测序所带来的影响分享了各自的观点。

Pharmacogenomics and Cardiovascular Disease
药物遗传学与心血管疾病

了解研究人员如何利用Illumina芯片鉴定失败的胆固醇药物试验中响应者的基因型。

Human Infinium Array Family
Human Infinium芯片系列

可为各种人类遗传分析研究提供支持的商业化联盟产品。

Human Genotyping Solutions
人类基因分型芯片解决方案

llumina基因分型芯片是灵活、可靠的SNP和结构变异筛查手段。

Illumina Technologies
Illumina的技术

我们的新一代测序和芯片技术支持广泛的基因组学应用。

Genomics and Neurodegenerative Diseases
基因组学与神经退行性疾病

高通量基因组学研究有助于深入了解阿尔茨海默病和帕金森病等疾病的相关基因和通路。

Developing a CogChip for ADHD Studies
Developing a CogChip for ADHD Studies

In collaboration with consortium studies, Dr. Mark Bellgrove is developing a genotyping array to study cognitive control.

参考文献
  1. NIH provides funding to H3Africa as part of the Common Fund Global Health initiative; the use of any company, commercial product and/or service by H3Africa grantees does not imply endorsement by NIH.