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Infinium Global Diversity Array with Cytogenetics-8
Microarray, RUO, DNA

Infinium Global Diversity Array with Cytogenetics-8

Profile clinical research variants associated with congenital disease, cancer research, pharmacogenomics (PGx), and exome content with this microarray.

Overview

The Infinium Global Diversity Array with Cytogenetics-8 is a scalable, cost-effective microarray that contains approximately 1.8M probes, with 160K probes supplementing the current Global Diversity Array manifest across more than 4800 tiered genes. Supplemental probes were selected based on the input from a cytogenetics research consortium and strategically localized near exons, in spatial consideration of existing probe placement, to deliver optimal performance in copy number variation analysis.

  • Detect structural variation in the human genome, including duplications, deletions, amplifications, copy-neutral loss of heterozygosity, and mosaicism.

  • Examine cytogenomic changes in constitutional diseases, cancers, and more.

  • Process sample types including saliva, blood, and buccal swabs using the PCR-free Infinium HD Assay with only 200 ng DNA per sample.

  • Analyze formalin-fixed paraffin-embedded (FFPE) paired tumor-normal samples when used with the appropriate FFPE cluster file.

Broad clinical research applications

Markers were selected from clinical research databases, including ClinVar, CPIC, and PharmGKB, for a variety of research applications, including risk profiling, pharmacogenomics, wellness characterization, and disease discovery.

Specifications

Assay time 3 days
Automation capability Automated array loader, Liquid handling robot(s)
Cancer type Hematologic, Solid tumor
Description The 8-sample Infinium Global Diversity Array with Cytogenetics-8 provides extensive targeted coverage of more than 4800 key genes across the genome. Approximately 1.8M markers are included on the BeadChip for high exonic coverage in regions of disease relevance, providing highly accurate copy number variation calls, and an average resolution of 1.5Mb.
Hands-on time 1 hour and 5 minutes for automated 8-beadchip workflow
Input quantity 200 ng DNA
Instruments iScan System
Method Cytogenomic array, Genome-wide genotyping array
Nucleic acid type DNA
Number of samples 8 samples per array
Specialized sample types Blood, FFPE tissue, Buccal swabs, Saliva
Species category Human
Technology Microarray
Variant class Single nucleotide polymorphisms (SNPs), Loss of heterozygosity (LOH), Chromosomal abnormalities, Copy number variants (CNVs)

Applications

Example workflow

1
Select content

Infinium Global Diversity Array with Cytogenetics-8

2
Process and scan
3
Analyze and report

BioDiscovery NxClinical Software

Related applications and methods

Chromosomal microarray analysis

Chromosomal microarrays reliably detect copy number and allelic contribution imbalances associated with constitutional disorders.

Cytogenomics

Together, next-generation sequencing and arrays enable cytogenomic analysis of chromosome aberrations for constitutional and cancer research.

Copy number variation analysis

Perform high-resolution copy number variation (CNV) analysis with Illumina array and next-generation sequencing solutions.

How others use this product
Exploring variants of unknown significance with cytogenetic microarrays

Documentation

Product literature
Support documentation

Compare

Infinium Global Diversity Array with Cytogenetics-8 Infinium Global Diversity Array-8 Kit Infinium CytoSNP-850K BeadChip
Assay time 3 days 3 days
Automation capability Automated array loader, Liquid handling robot(s) Automated array loader, Liquid handling robot(s) Automated array loader, Liquid handling robot(s)
Cancer type Hematologic, Solid tumor Hematologic, Solid tumor
Description The 8-sample Infinium Global Diversity Array with Cytogenetics-8 provides extensive targeted coverage of more than 4800 key genes across the genome. Approximately 1.8M markers are included on the BeadChip for high exonic coverage in regions of disease relevance, providing highly accurate copy number variation calls, and an average resolution of 1.5Mb. The 8-sample Infinium Diversity Array provides targeted coverage of more than 4800 key genes across the genome. Approximately 1.8M markers are included on the BeadChip for high exonic coverage in regions of disease relevance, providing highly accurate copy number variation calls, and an average resolution of 1.5Mb. The Infinium CytoSNP-850K BeadChip enables high-resolution analysis for discovery of meaningful chromosomal aberrations through disease-focused coverage of 3262 genes of known cytogenetics relevance.
Hands-on time 1 hour and 5 minutes for automated 8-beadchip workflow 1 hr 5 min for automated 8-beadchip workflow, 6 hr 15 min for manual 8-beadchip workflow
Input quantity 200 ng DNA 200 ng DNA 200 ng DNA
Instruments iScan System iScan System NextSeq 550 System, iScan System
Method Cytogenomic array, Genome-wide genotyping array Genome-wide genotyping array Cytogenomic array, Genome-wide genotyping array
Nucleic acid type DNA DNA DNA
Number of samples 8 samples per array 8 samples per array 8 samples per array
Specialized sample types Blood, FFPE tissue, Buccal swabs, Saliva Blood, FFPE tissue, Buccal swabs, Saliva FFPE tissue, Blood, Saliva
Species category Human Human Human
Technology Microarray Microarray Microarray
Variant class Single nucleotide polymorphisms (SNPs), Loss of heterozygosity (LOH), Chromosomal abnormalities, Copy number variants (CNVs) Single nucleotide polymorphisms (SNPs), Loss of heterozygosity (LOH), Chromosomal abnormalities, Structural variants, Copy number variants (CNVs) Single nucleotide polymorphisms (SNPs), Loss of heterozygosity (LOH), Chromosomal abnormalities, Copy number variants (CNVs)

Infinium Global Diversity Array with Cytogenetics (8 Samples)

20122861

The Infinium Global Diversity Array with Cytogenetics Content, 8 Samples Kit combines a versatile disease-focused genome-wide backbone with optimized content for advanced cytogenetic analysis. Each BeadChip assays ~1.8M total variants. Each kit contains 1 BeadChip and the necessary reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 8 samples.

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Infinium Global Diversity Array with Cytogenetics (16 Samples)

20066507

The Infinium Global Diversity Array with Cytogenetics, 16 Samples Kit combines a versatile disease-focused genome-wide backbone with optimized content for advanced cytogenetic analysis. Each BeadChip assays ~1.8M total variants. Each kit contains 2 BeadChips and the necessary reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 16 samples.

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Infinium Global Diversity Array with Cytogenetics (48 Samples)

20066508

The Infinium Global Diversity Array with Cytogenetics, 48 Samples Kit combines a versatile disease-focused genome-wide backbone with optimized content for advanced cytogenetic analysis. Each BeadChip assays ~1.8M total variants. Each kit contains 6 BeadChips and the necessary reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 48 samples.

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Infinium Global Diversity Array with Cytogenetics (96 Samples)

20066509

The Infinium Global Diversity Array with Cytogenetics, 96 Samples Kit combines a versatile disease-focused genome-wide backbone with optimized content for advanced cytogenetic analysis. Each BeadChip assays ~1.8M total variants. Each kit contains 12 BeadChips and the necessary reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 96 samples.

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Infinium Global Diversity Array with Cytogenetics (384 Samples)

20066510

The Infinium Global Diversity Array with Cytogenetics, 384 Samples Kit combines a versatile disease-focused genome-wide backbone with optimized content for advanced cytogenetic analysis. Each BeadChip assays ~1.8M total variants. Each kit contains 48 BeadChips and the necessary reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 384 samples.

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Services (1)

Infinium® Assay: An Introduction – Customer Site

20015273

Three-day, hands-on instruction at customer site to familiarize users with the essential steps in the Infinium protocol. Course provides hands-on training in sample and BeadChip preparation, sample scanning using the iScan System, and primary data evaluation and analysis using array analysis software.

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