TruSight Oncology 500
此分析方法靶向多种变异类型，包括肿瘤突变负荷（TMB）和微卫星不稳定性（MSI），即使是低质量样本同样适用。Read More...
TruSight Oncology 500是新一代测序（NGS）检测方法，支持肿瘤样本的全景基因组图谱分析。它能够鉴定各种肿瘤类型中涉及的所有相关DNA和RNA*变异。
此外，它还能准确测量关键免疫疗法生物标记：肿瘤突变负荷（TMB）和微卫星不稳定性（MSI）。
通过检测整合节省时间、费用和样本
获得可信度高的结果
解锁免疫肿瘤学
*评估DNA和RNA变异所采用的产品为TSO500 DNA/RNA Bundle。
The TruSight Oncology 500 Analytical Evaluation Service* is a set of tools intended to guide you in aligning with the latest CAP, AMP, and European standards. We provide recommendations to help you evaluate analytical performance characteristics and integrate products into your workflows.
Learn More
* This service is available in select countries and regions.
| Pan-Cancer Biomarkers NTRK1 NTRK2 NTRK3 MSI TMB (Emerging) |
||||||||
|---|---|---|---|---|---|---|---|---|
| Lung | Melanoma | Colon | Ovarian | Breast | Gastric | Bladder | Myeloid | Sarcoma |
| AKT1 | BRAF | AKT1 | BRAF | AKT1 | BRAF | MSH5 | ABL1 | ALK |
| ALK | CTNNB1 | BRAF | BRCA1 | AR | KIT | PMS2 | ASX1 | APC |
| BRAF | GNA11 | HRAS | BRCA2 | BRCA1 | KRAS | TSC1 | CALR | BRAF |
| DDR2 | GNAQ | KRAS | KRAS | BRCA2 | MET | CEBPA | CDK4 | |
| EGFR | KIT | MET | PDGFRA | ERBB2 | MLH1 | ETV6 | CTNNB1 | |
| ERBB2 | MAP2K1 | MLH1 | FOXL2 | FGFR1 | PDGFRA | EZH2 | ETV6 | |
| FGFR1 | NF1 | MSH2 | TP53 | FGFR2 | TP53 | FLT3 | EWSR1 | |
| FGFR3 | NRAS | MSH6 | PIK3CA | GATA2 | FOXO1 | |||
| KRAS | PDGFRA | NRAS | PTEN | IDH1 | GLI1 | |||
| MAP2K1 | PIK3CA | PIK3CA | IDH2 | KJT | ||||
| MET | PTEN | PMS2 | JAK2 | MDM2 | ||||
| NRAS | TP53 | PTEN | KIT | MYOD1 | ||||
| PIK3CA | SMAD4 | MPL | NAB2 | |||||
| PTEN | TP53 | NPM1 | NF1 | |||||
| RET | RUNX1 | PAX3 | ||||||
| TP53 | SF3B1 | PAX7 | ||||||
| TMB | SRSF2 | PDGFRA | ||||||
| TP53 | PDGFRB | |||||||
| SDHB | ||||||||
| SDHC | ||||||||
| SMARCB1 | ||||||||
| TFE3 | ||||||||
| WT1 | ||||||||
The genes and biomarkers listed in this table are a subset of all genes included in the panel. To see the full gene list, view the product datasheet, available under Product Literature on this page.
* The product to evaluate DNA & RNA variants is the TruSight Oncology 500 DNA/RNA Bundle.
Optimizing RNA input to detect gene fusions with TruSight Oncology 500 High-Throughput
Technical Note | PDF< 1 MB
Input Recommendations for TMB, MSI, and Small Variant Analysis with TruSight Oncology 500
Technical Note | HTML
Analysis of TMB and MSI Status with TruSight Oncology 500
Application Note | HTML
Simplifying the process to identify applicable variants in oncology samples
Brochure | PDF2 MB
Data Sheet | PDF | 4 versions
TruSight Oncology 500 Gene List
product_file | EXCEL< 1 MB
Provides comprehensive gene fusion detection in formalin-fixed, paraffin-embedded (FFPE) and other cancer research samples.
* Based on PierianDx Clinical knowledgebase, as of March 2020
