TruSight Oncology 500

此分析方法靶向多种变异类型,包括肿瘤突变负荷(TMB)和微卫星不稳定性(MSI),即使是低质量样本同样适用。 Read More...
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TruSight Oncology 500 DNA Kit(48样本)

20028213

TruSight Oncology 500 DNA Kit,配合NextSeq使用(48样本)

20028214

TruSight Oncology 500 DNA/RNA Bundle(16标签,24样本)

20028215

TruSight Oncology 500 DNA/RNA Bundle,配合NextSeq使用(16标签,24样本)

20028216

TruSight Oncology 500 DNA Kit,外加PierianDx解读报告(16标签,48样本)

20032624

TruSight Oncology 500 DNA Kit,配合NextSeq使用,外加PierianDx解读报告(16标签,48样本)

20032625

TruSight Oncology 500 DNA/RNA Bundle,外加PierianDx解读报告(16标签,24样本)

20032626

TruSight Oncology 500 DNA/RNA Kit,配合NextSeq使用,外加PierianDx解读报告(16标签,24样本)

20032627

Product Highlights

TruSight Oncology 500是新一代测序(NGS)检测方法,支持肿瘤样本的全景基因组图谱分析。它能够鉴定各种肿瘤类型中涉及的所有相关DNA和RNA*变异。

此外,它还能准确测量关键免疫疗法生物标记:肿瘤突变负荷(TMB)和微卫星不稳定性(MSI)。

通过检测整合节省时间、费用和样本

  • 泛癌内容与关键指南和临床试验相匹配
  • DNA和RNA*分析靶向523个基因,可评估小变异、TMB、MSI、剪接变异和融合
  • 可鉴定相关变化,同时获得高度精确的结果

获得可信度高的结果

  • 使用软件过滤杂峰,准确检出变异
  • 富集测序化学技术包括独特的分子标签(UMI),可实现高灵敏度的变异检测
  • 以成熟的Illumina平台为基础

解锁免疫肿瘤学

  • Panel包含免疫肿瘤学生物标记TMB和MSI
  • 仅肿瘤工作流程简单高效
  • TMB检出性能与全外显子组测序(WES)panel相似
  • 1.94 Mb的大型panel和复杂的算法可获得精确的TMB分数

*评估DNA和RNA变异所采用的产品为TSO500 DNA/RNA Bundle。

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规格

具体的方法工作流程范例

 

支持数据和图像

 
Detection of currently relevant DNA & RNA* variants for multiple types of cancer. Some key biomarkers include:
Pan-Cancer Biomarkers
NTRK1        NTRK2        NTRK3        MSI        TMB (Emerging)
Lung Melanoma Colon Ovarian Breast Gastric Bladder Myeloid Sarcoma
AKT1 BRAF AKT1 BRAF AKT1 BRAF MSH5 ABL1 ALK
ALK CTNNB1 BRAF BRCA1 AR KIT PMS2 ASX1 APC
BRAF GNA11 HRAS BRCA2 BRCA1 KRAS TSC1 CALR BRAF
DDR2 GNAQ KRAS KRAS BRCA2 MET   CEBPA CDK4
EGFR KIT MET PDGFRA ERBB2 MLH1   ETV6 CTNNB1
ERBB2 MAP2K1 MLH1 FOXL2 FGFR1 PDGFRA   EZH2 ETV6
FGFR1 NF1 MSH2 TP53 FGFR2 TP53   FLT3 EWSR1
FGFR3 NRAS MSH6   PIK3CA     GATA2 FOXO1
KRAS PDGFRA NRAS   PTEN     IDH1 GLI1
MAP2K1 PIK3CA PIK3CA         IDH2 KJT
MET PTEN PMS2         JAK2 MDM2
NRAS TP53 PTEN         KIT MYOD1
PIK3CA   SMAD4         MPL NAB2
PTEN   TP53         NPM1 NF1
RET             RUNX1 PAX3
TP53             SF3B1 PAX7
TMB             SRSF2 PDGFRA
              TP53 PDGFRB
                SDHB
                SDHC
                SMARCB1
                TFE3
                WT1

The genes and biomarkers listed in this table are a subset of all genes included in the panel. To see the full gene list, view the product datasheet, available under Product Literature on this page.

* The product to evaluate DNA & RNA variants is the TruSight Oncology 500 DNA/RNA Bundle.

产品资料

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TruSight Oncology 500 Gene List

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